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At a molecular level, smoking affects key signaling pathways such as nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinases (MAPK) and induces epigenetic modifications like DNA methylation and histone modification [22]
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This data can be found at: 2022 Canadian Guidance on Alcohol and Health: MPoRT Model data: Author contributions HJ: Formal analysis, Investigation, Writing original draft, Writing review & editing
In lung cancer, PD-1/PD-L1 checkpoint inhibitors boost anti-tumor immunity, trastuzumab targets HER2 mutations, rituximab depletes CD20 + B cells, and CRISPR-Cas9 corrects disease-causing mutations

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Australian and New Zealand Journal of Public Health, 40 (3), 221225
