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The researchers replicated the study using patients with Type 2 diabetes, and found similar results Kidney Disease: Semaglutide Could Prevent Chronic Issue Participants taking semaglutide who had Type 2 diabetes and chronic kidney disease had a 24% lower chance of experiencing a major kidney-related event like kidney failure, according to research by the New England Journal of Medicine

Discussion This systematic review focuses on the regulatory effect of semaglutide on BP in subjects with T2DM

In the Phase 2 clinical trial, participants generally met the following criteria: Body mass index (BMI) of 27 kg/m or above with at least one weight-related comorbidity (such as hypertension, dyslipidaemia, or obstructive sleep apnoea), or a BMI of 30 kg/m or above without comorbidities

For weight management, NICE (TA664) recommends these medications within specialist weight management services for people with a BMI of at least 35 kg/m (or 32.5 kg/m in people from minority ethnic backgrounds) with non-diabetic hyperglycaemia and a high risk of cardiovascular disease, or a BMI of at least 30 kg/m with type 2 diabetes

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