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Monitor blood sugars closely if you take insulin or sulfonylureas to avoid low blood sugar episodes

A search of the trial literature and registries finds retatrutide studied in obesity, in type 2 diabetes, in MASLD, in knee osteoarthritis with obesity, and in cardiovascular-disease populations but not in a cohort defined by PCOS, and not with PCOS-specific reproductive or androgen endpoints

Employers that go this route should educate employees and communicate very clearly about the eligibility conditions and documentation required by the plan and under IRS rules

Market Growth and Pressure to Expand Access The GLP1 weight loss market in South Africa brought in around R989 million in 2024

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Sources: Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine Realworld use and effectiveness of tirzepatide among individuals without type 2 diabetes: Results from the Optum Market Clarity database PMC Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity | Obesity | JAMA Internal Medicine | JAMA Network Semaglutide StatPearls NCBI Bookshelf Safety of Semaglutide PMC Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes PMC Realworld evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP1RAbased weightloss therapies PMC Liraglutide for weight management: a critical review of the evidence PMC Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus PMC Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network