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Hydration deserves equal attention: semaglutide's mechanism and reduced food intake both increase dehydration risk

When digestion is slowed, food can accumulate in the intestines, which can increase the risk of a blockage

Recommendations regarding GLP-1RA discontinuation before conception are largely derived from animal data, with suggested washout periods ranging from one to three months

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A meta-analysis shows that individuals with systolic blood pressure of 140 mmHg or higher or diastolic blood pressure of 80 mmHg or higher in middle age have a 37% increased risk of dementia later in life

Despite the lack of GLP-1R expression, GLP-1RAs appear to have a positive effect on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), as evidenced by a clinical trial with liraglutide and now under further investigation in clinical trials with semaglutide (109, 110)