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Surg Obes Relat Dis 14(9):13681372 Brown AM, Yang J, Zhang X, Docimo S, Pryo AD, Spaniolas K (2022) Bariatric surgery lowers the risk of major cardiovascular events
Better absorption of nutrients
GCGR activation, represented in green, is unique in that glucagon receptors are robustly expressed on hepatocytes, enabling direct liver-directed metabolic effects - a mechanistic feature absent from both GLP-1R and GIPR signaling
Echocardiographic studies demonstrate that GLP-1 agonists improve global longitudinal strain, an early marker of subclinical diabetic cardiomyopathy, by 1520% [79]
[3] Rubino, D., et al
the other strategy includes injectable GLP-1R agonists that mimic human GLP-1 or nonmammalian GLP-1R agonists
