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Some people lost up to 24% of their body weight

In one study, patients regained about two-thirds of the weight they had lost just one year after stopping semaglutide treatment, and their cardiometabolic risk markers (blood sugar, cholesterol, etc.) reverted toward baseline (source)

We hope that this work will help us understand why these receptors work differently to each other, why they have different strengths at triggering the release of insulin and glucagon, and how changes in the genes that code for them modify the way they work in specific people.

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Introduction The remarkable growth in the use of Glucagon-Like Peptide-1 receptor agonists (GLP-1 RAs) in recent years has drawn attention to a class of drugs that have proven to be highly effective in managing type 2 diabetes mellitus (T2DM) and mitigating the effects of its numerous complications

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