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of four RCTs with 176 participants demonstrated that GLP1-RAs significantly reduced waist circumference (MD: 5.16 cm), BMI (MD: 2.42 kg/m 2 ), serum triglycerides (MD: 0.20), and total testosterone levels (MD: 1.33) compared to placebo [129]

The key unanswered question is whether retatrutide's greater absolute weight loss is offset by its higher side effect burden and the new dysesthesia safety signal

What to Expect Based on Your Starting Weight Your starting weight influences both your expected results and your likely side effect experience

Patients on tightly-titrated diabetes medications need a careful intake to avoid hypoglycemia from amplified insulin sensitivity