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UAE was prevalent in the cited studies, employing solvents ranging from hydroethanolic mixtures [38,41] and organic acids [27,36] to innovative NADES/DES solvents [39,40]

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Sources include: the FDA Orange Book (for small molecules), the FDA Purple Book (for biologics, with awareness of its incompleteness), company 10-K and 10-Q filings (which disclose P.IV notices received and patent litigation), court dockets for pending Hatch-Waxman and BPCIA litigation, and third-party patent intelligence platforms that aggregate and analyze these data sources

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The recommended daily allowance for zinc is 8-11mg for adults, though slightly higher doses (15-30mg) have been used in studies examining metabolic effects