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That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine

It's motivation to eat better and start exercising

Adverse Reactions / Side Effects Nausea Diarrhea Decreased appetite Vomiting Constipation Dyspepsia (indigestion) Abdominal pain If side effects are severe or persistent, contact your healthcare provider

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This triple GLP-1/GIP/glucagon receptor agonist represents a newer pharmacological approach, and proper injection technique combined with medical supervision is critical for safe, effective use