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Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-B Signaling in Insulin-Positive Differentiation of AR42J Cells

Elevated concentrations of postprandial triglyceride-rich lipoproteins (TRLs) are associated with an increased incidence of cardiovascular disease (1), and therapies that lower triglycerides (TGs) have demonstrated cardiovascular benefit (2)

In a pooled analysis of clinical trials assessing patients with heart failure with preserved ejection fraction (HFpEF), including the STEP HFpEF and STEP HFpEF DM trials, as well as in the FLOW and SELECT trials, semaglutide improved New York Heart Association (NYHA) class IIIV symptoms, physical limitations, exercise function, associated with a 30% reduction of N-terminal pro-brain natriuretic peptide and a 31% reduction in the composite endpoint of cardiovascular death and the need for treatment intensification or hospitalization for heart failure-related events (HR 0.69

We identified 20 metabolites possibly involved in carbohydrate metabolism which differed between the two groups, including increased carnitine and acylcholines in PBH