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Some regulate hunger, others influence hormone balance, and many support tissue repair

Elevated TMAO levels have been associated with increased risks of atherosclerosis, cardiovascular disease, and higher all-cause mortality in multiple epidemiological studies

535 Other studies by the same research team consistently found that combinations of pycnogenol plus gotu kola extract increased plaque stability and/or reduced the number and size of plaques, as assessed by ultrasound, in atherosclerosis patients

(3) Contraindications History of cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension) (4) During or within 14 days following the administration of monoamine oxidase inhibitors (4) Hyperthyroidism (4) Glaucoma (4) Agitated states