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Evaluation of the Incretin Effect in Humans Using GIP and GLP-1 Receptor Antagonists

Some healthcare providers will prescribe Rybelsus off-label for weight loss for patients who meet eligibility

Conversely, patients with long-standing obesity, multiple previous weight loss attempts, or significant metabolic dysfunction may benefit from indefinite therapy

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The possibility that GLP-1 medicines could reduce craving or alter reward-related behaviour has become an active area of investigation, particularly as these drugs become more widely used for diabetes, obesity and weight management

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