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Anti-inflammatory effect of exendin-4 postconditioning during myocardial ischemia and reperfusion

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This is precisely why the class was, for two decades, an injectable-only class, and why the one oral peptide agonist that reached market oral semaglutide requires an elaborate absorption-enhancer technology (the sodium N-(8-[2-hydroxybenzoyl]amino)caprylate carrier, or SNAC) plus strict dosing rules: take on an empty stomach, with no more than about 120 mL of plain water, then wait at least 30 minutes before eating, drinking, or taking other medications
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