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Contact your GP if urine colour changes persist despite adequate hydration or if you have ongoing gastrointestinal side effects affecting fluid intake

A Surgeons Viewpoint Cosmetic surgeons observe how weight loss from medications such as retatrutide molds the physique and influences the surgical experience

GLP-1 specifically inhibits glucagon secretion, which is especially advantageous for individuals with type-2 diabetes (T2DM) who often have increased glucagon levels

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Week 1-4 Experience: You'll start on the lowest dose to promote tolerance Some patients notice reduced appetite within days Others take a few weeks to feel significant changes Mild side effects like nausea are most common early on Your doctor monitors your response and addresses concerns Most patients begin seeing measurable weight loss within the first 3-4 weeks, though the most significant results typically occur after several months as doses gradually increase

[Abstract] PLoS One