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In Pennsylvania, a $3.5 billion facility in Fogelsville, announced in January 2026 and beginning construction in 2026, will manufacture tirzepatide and next-generation peptides including retatrutide, with completion expected in 2031

Lancet Diabetes Endocrinol 2024

Semaglutide Side Effects and Safety Semaglutide is generally well tolerated, with the most common side effects being nausea, mild vomiting, diarrhea, or constipation particularly during the early dose escalation phase

FDA approval could occur in 2028 or beyond

10.1186/s13048-015-0161-3 J Ovarian Res