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Even in healthy adults, the GI burden is real and the long-term unknowns remain

Today, a new generation of GLP-1 receptor agonists has transformed obesity and metabolic disease research and treatment

These unchanged insulin levels most likely reflect the GLP-1 agonists ability to help glucose stimulate beta-cell production leading to a decreased work load thereby creating a more normal ratio of glucose and insulin

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This isn't specific to patches, but it applies to the broader unregulated weight loss supplement market these products sit within

Diabetes Res Clin Pract 94: 199206