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GLP-1 receptor agonists and hormonal birth control can be used together safely in most cases, though gastrointestinal effects may reduce oral contraceptive absorption in rare instances

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However, in the preplanned subgroup analysis looking only at patients who were or were not taking SGLT2 inhibitors or GLP-1RAs, the average difference in peak VO2 between the AT-001 group and the placebo group was 0.64, which was both statistically and clinically significant, Januzzi said