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doi: 10.1111/pedi.13129 113 CioanaMDengJNadarajahAHouMQiuYChenSSJet al

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Gastrointestinal side effects are the most commonly reported adverse reactions with GLP-1 receptor agonists

By adding glucagon receptor agonism to the dual GIPR/GLP-1R mechanism pioneered by Tirzepatide, Retatrutide achieves a broader metabolic profile that includes hepatic fatty acid oxidation via GCGR activation, a mechanism proposed to confer additional benefit in non-alcoholic fatty liver disease (NAFLD) research models beyond what GLP-1R agonism alone can produce