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There is accumulating evidence for numerous additional mechanisms of action separate from SGLT2 inhibition that appear to underlie the ability of gliflozins to produce additional effects associated with favorable outcomes, such as in the reduction of mortality and CV events in patients with heart failure
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8.5 Geriatric Use In the pool of glycemic control trials, 1,229 (30%) patients treated with semaglutide tablets were 65 years of age and over and 199 (5%) patients treated with semaglutide tablets were 75 years of age and over [see Clinical Studies (14)]

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