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Missing three or more doses effectively resets your body tolerance

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The trade-off is reduced potency

It has also been suggested that brain penetrance differs between different GLP-1 analogs, with nonacylated and non-PEGylated analogs like exendin-4 or lixisenatide showing significant rates of brain influx, while liraglutide or semaglutide do not have reliable BBB crossing (143), at least in male mice