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Various studies have attempted to quantify how much fat versus muscle mass is being lost when using GLP-1 agonists and the results vary anywhere from 20 to 50% of total weight loss as lean body mass (3) (muscle mass)

However, due to frequent changes in product offerings, market conditions, and regulatory approvals, some details may become outdated or incorrect over time

And every kilogram of muscle lost reduces resting metabolic rate by ~13 kcal/day, making long-term weight maintenance much harder

How semaglutide works: the GLP-1 single agonist Semaglutide activates one receptor: the glucagon-like peptide-1 (GLP-1) receptor

The DGA frames this from a population health perspective, encouraging home-prepared meals and overall dietary quality, while the ADA applies the same principles within the context of diabetes care, where food choices directly affect glycemia, cardiometabolic risk, and long-term outcomes