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La precocidad de la separacin de las curvas de aparicin de MACE entre los brazos de SEMA y placebo23 sugiere una potencial participacin directa de SEMA en los resultados del estudio SELECT, a travs de efectos promotores de angiognesis y reduccin de estrs oxidativo e inflamacin, en el contexto de acciones antiaterognicas derivadas de la activacin del GLP-1R que favorecen la funcin endotelial y la supervivencia celular7 (fig

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from 2017 to 2022, most notably in the 65 and older age cohort (66.4%) and the 20-44 age cohort (58.5%)

It is also a reminder that the real-world effects of GLP-1 drugs are often broader than the trial headlines suggest

This interconnection means that the inflammatory benefit is not one benefit among many

And how about side effects when switching between the two