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Retatrutide works by binding to and stimulating the GLP-1 GIP and glucagon receptors simultaneously

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Compared with other PPAR agonists lanifibranor, rosiglitazone,and elafibranor, pioglitazone had a greater effect on steatosis, hepatocyte ballooning, inflammation, and fibrosis

The injection is placed just under the skin, often in the stomach or upper arm

(Phase 2 anchor trial: 24.2% body weight loss at 48 weeks on 12mg, n=338, dose-response across 1mg/4mg/8mg/12mg arms.) Eli Lilly and Company

These secondary benefits can be especially valuable for patients who are overweight or obese and already dealing with hypertension, dyslipidemia, or other cardiac risk factors