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Key Differences in How Tirzepatide Works Compared to Semaglutide Semaglutide exclusively activates GLP-1 receptors, which signal fullness, slow gastric emptying, and reduce hunger in the brain's appetite centers

The GLP-1-mediated glucose lowering offsets the hyperglycemic tendency of glucagon receptor activation

Profound appetite elimination

Zepbound and Papillitis: Zepbound has been associated with other disorders of the optic nerve and visual pathways

doi: 10.1016/S2213-8587(19)30068-3

They are also prescribed for patients who are overweight, i.e ., those with a BMI of greater than 27, and who also have one weight-related condition, such as hypertension, hyperlipidemia or sleep apnea