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Mecanismo de accin de los agonistas duales GLP-1/GIP Los agonistas duales actan sobre los receptores GLP-1 R y GIP R, ambos acoplados a protenas Gs, estimulando la adenilato ciclasa y aumentando los niveles intracelulares de AMP cclico (AMPc) en las clulas beta pancreticas

Phase 3 efficacy and safety trial of proposed liraglutide biosimilar for reduction of glycosylated hemoglobin (HbA1c) in patients with Type 2 diabetes mellitus

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However, this was a small study with significant limitations, and berberine is not a substitute for prescribed diabetes treatment or any other medical therapy