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Circadian rhythm, the internal clock that governs when you feel sleepy and when you feel alert, may also be affected

Lys 16 Replacing the Gly 22 of GLP-1 with Ala or Aib slightly decreased both its affinity and activity (Ala IC 50 : 0.27 nM0.57 nM;EC 50 : 2.6 nM4 nM)

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Relevant aggregate data supporting the conclusions of the manuscript are provided in the supplementary materials