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10.1038/npjpcrm.2015.5 [EL2

Control Cohort: Patients not receiving semaglutide, matched for baseline demographic and clinical characteristics

SAT is characterized by more numerous small adipocytes, and it is more insulin-sensitive than VAT due to a higher expression of IRS-1, protecting it from insulin resistance [60,62]

Given the role of GLP-1RAs and other incretin-based medications widely used for the treatment of T2D and obesity, surprisingly little research has been directed at a comprehensive assessment of even the most frequent GI adverse events (125)

And also remember there are non-hormological therapies such as oxybutynin, and gabapentin, that may help patients

Patients experiencing significant gastrointestinal symptoms should focus on tolerating their prescription medication before adding supplements