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Rybelsus is designed to be taken on an empty stomach in the morning with no more than 4 oz of plain water, says Gia Eapen, MD

Semaglutide trials (STEP program) reported nausea in approximately 25-35% of participants at therapeutic doses

Knowing more about these factors will help us use GLP-1 medications better

Tirzepatide (Zepbound, Mounjaro) Tirzepatide works similarly to semaglutide, but in addition to mimicking GLP-1, tirzepatide also mimics the hormone GIP (which stands for glucose-dependent insulinotropic polypeptide)

The GIP component appears to reduce nausea severity compared with GLP-1 monotherapy at equivalent efficacy, a distinguishing feature of the compound

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