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Dose reduction of concomitant medications is typically required when initiating GLP-1 or dual-agonist therapy

However, research has also shown promising weight loss results when therapies are combined

Semaglutide's adverse events primarily stem from its effects on gastrointestinal motility and gastric emptying

Fiber additives (chicory root, inulin, soluble corn fiber) Highly fermentable isolated fibers that cause bloating and gas, especially on a slowed GLP-1 stomach

GLP-1 receptor agonists slow gastric emptying (though less so at microdoses)

After the addition of the permeabilized tissue, the respirometer chambers were hyperoxygenated to ~350 nmol/mL