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Weight reduction that is substantial (14%) and rapid (over 3-4 mo) is associated with significant bone loss, 71 whereas more moderate and slower weight reduction may better preserve bone mass

Bupropion-naltrexone (Contrave) Contrave combines an antidepressant (bupropion) with an opioid antagonist (naltrexone) to target reward-based eating behaviors

GIP Glucose-dependent insulinotropic polypeptide The GLP-1 medications Saxenda (liraglutide) and Wegovy (semaglutide) use just one mechanism of action, that is, they activate GLP-1 receptors and cause all of the above effects on appetite regulation and body weight

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Whole-brain activation signatures of weight-lowering drugs

Some programs offer access to branded GLP-1 medications that are injectable, as well as personalized oral medication kits that may include ingredients like metformin, bupropion, topiramate, vitamin B12, or naltrexone