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For example, a clinical trial involving semaglutide reported that participants with a baseline body mass index (BMI) over 35 kg/m lost an average of 15% of their body weight after 68 weeks, while those with lower baseline weights lost less in relative terms

5 , e508e522 (2023)

This matters for a practical reason

A 2017 meta-analysis found no significant increase in pancreatitis or pancreatic cancer risks (odds ratios 0.93 and 0.94, respectively)

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Resistance training and adequate protein intake (at least 1 gram per pound of ideal body weight) are essential to minimize muscle loss