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Lancet Diabetes Endocrinol 2021;9:825-36.ArticlePubMed 129

Nevertheless, those findings about the incomplete abolition of the glucagon response in Fgf21 null mice open doors to additional GCGR-dependent mechanisms, which could contribute to the acute GCG-dependent enhancement of energy expenditure [43]

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For those taking insulin or sulfonylureas, this may increase hypoglycaemia risk, requiring medication review