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This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group

doi:10.1210/jcem.85.8.6717 59 YustaBMatthewsDFlockGBUssherJRLavoieBMaweGMet al

Researchers compared women who did or did not receive a GLP-1 receptor agonist prescription within 24 months of pregnancy, matching the two groups by age, race, ethnicity and history of comorbid conditions

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Such localized colonic release limits systemic exposure, thereby minimizing side effects like nausea [389]