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Switching to single or dual agonist medications would likely produce inferior results

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The combined metabolic footprint would be broader than either compound alone, touching more systems through more pathways

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DPP-4 is an integral membrane protein which has a widespread distribution, being expressed in numerous tissues including intestinal and renal brush border membranes, vascular endothelium, the liver and pancreas, glandular epithelial cells, and by cells of the immune system (where it is also known as the T-cell differentiation antigen, CD26)