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The intensity depends on how much your caloric intake drops, how large your glycogen stores were to begin with, and how your kidneys handle the fluid shift

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Effective pharmacotherapy for obesity is likely to require long-term, if not life-long, treatment, which makes it important to consider long-term adherence and weight loss efficacy, and the effects on obesity co-morbidities (particularly cardiovascular outcomes), safety (including potential adverse effects on muscle mass and bone health), and cost of poly-agonist therapy

Medical weight-loss clinics are able to provide doctor-supervised weight-loss treatment plans that typically consist of a balance of a healthy diet, regular exercise, and potentially weight-loss medication to aid the process if necessary

Once thyroid function is stable, thyroid function tests are typically performed annually, but more frequent testing is warranted during active weight loss
