mechanism glp 1 receptor agonist GLP-1 Agonists Explained for Pharmacy & Medical Students: Mechanism, Uses, and Side Effects GLP-1 Receptor Agonists and Myocardial

A large retrospective study by Best et al compared patients treated with exenatide, a GLP-1 analog, to those treated with other glucose-lowering drugs, and found a 20% decrease in cardiovascular events

Summary Although GLP-1R agonists were originally developed for glycemic control in DM, their mechanistic versatility has enabled broader application across a spectrum of cardiovascular, cerebrovascular and metabolic disorders

Joint health is also relevant, as excess weight compounds the joint pain that many menopausal women experience

Klein PS, Melton DA

GLP-1 also increases inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and Ryanodine receptors (RYR) receptor sensitivity to Ca+ 2 effects, aiding Ca+ 2-induced Ca+ 2 release (CICR)

Substrate-like inhibitors often include proline mimetics that occupy the S 1 site