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Methods Animals Male C57BL/JRj mice were purchased from Janvier Labs at 7 weeks old, and used in experiments at 8-18 weeks of age

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Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight

But, and this is a significant but, these were male rats, which is a particularly significant limitation given that fibromyalgia has an approximately 3:1 female-to-male prevalence ratio and reserpine-induced models have known sex differences in their mechanisms

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