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Risk of depression with GLP-1 receptor agonists use in overweight or obese adults with type 2 diabetes: a new-user, active-comparator cohort study

Start by defining personal health and quality-of-life goals that go beyond just weight loss, such as more energy, better mobility, or improved metabolic health

dose reductions of these medications may be needed when initiating GLP-1 therapy

There are likely to be a number of factors to account for this variability in efficacy, for example, our group (Zhou et al) recently established that the glycaemic response to metformin is moderately heritable, i.e

Patients with established cardiovascular disease Those with previous myocardial infarction, stroke, or peripheral arterial disease may benefit from the cardioprotective effects of certain GLP-1 receptor agonists, which include modest blood pressure reductions alongside other cardiovascular benefits

Several providers offer significant discounts for paying annually instead of monthly