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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

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Researchers examined data from more than 9,000 patients, sharing their findings at SCAI 2025.

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Combining semaglutide and retatrutide remains largely unstudied in humans, though both activate GLP-1 pathways