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Peptides (2016) 77:1620

Autonomic Nervous System Effects: These medications are known to enhance sympathetic nervous system activity, which could influence optic nerve head perfusion, making the nerve more susceptible to ischemic damage

Besides, the butyrate in SCFAs provides energy to the gut, repairs the structure of gut mucosa and villi, increases the absorption area of the gut, and increases the absorption and utilization of calcium in the gut

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Both produce similar indirect mechanisms for sleep disruption through appetite suppression, gastric slowing, and metabolic changes

But what exactly is happening in the brain, and how can clinicians explain it clearly