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The 2mg dose primarily activates GLP-1 with minimal glucagon receptor engagement

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The improvement of the hepatic histological findings in a patient with non-alcoholic steatohepatitis with type 2 diabetes after the administration of the sodiumglucose cotransporter 2 inhibitor Ipragliflozin

The dual-action setup might explain why it has been pulling ahead in some studies

Diabetologia 2010;53:2735 [DOI] [PubMed] [Google Scholar] 31
