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Several in vitro and in vivo results have expanded the role of these molecules from potentiating glucose-stimulated insulin secretion to promoting -cell survival under different stressful environments by favoring proliferation, neogenesis and resistance to apoptosis (3437)

Discontinuation appears to be multifactorial, with contributors including gastrointestinal side effects (3), treatment cost and access, patient expectations, and tolerability over time

Only some features of the GH-IGF-1 axis appear to be dependent on the different genotypes

doi: 10.1038/d41586-023-03143-x

"The hair loss is real" shedding despite steady calorie intake on GLP-1 therapy

Occasionally, non-diabetics will have a negative gastric emptying study and no evidence of delayed emptying, but when a liquid gastric emptying study is done it will be abnormal