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However, it is the topographical distribution of these receptors across functionally distinct brain regionsparticularly those implicated in motivation, reinforcement, and rewardthat has garnered increasing attention in the context of addiction neurobiology

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People who are otherwise healthy may be less willing to accept these potentially serious adverse events. Using a random sample of 16 million patients from the PharMetrics Plus database, Sodhi and colleagues evaluated gastrointestinal adverse events among new users of GLP-1 agonists liraglutide (n = 4,144) or semaglutide (n = 613) between 2006 and 2020

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