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Clinical prioritization of signals A semiquantitative score was employed to prioritize disproportionality signals in five features, including number of reports, the lower limit of the ROR 95% CI (ROR 025 ) values, proportion of death outcomes, assessment as designated medical events (DMEs) or important medical events (IMEs), and evidence evaluation (Supplementary Table S2

Even minor deviations in purity or content may significantly impact performance and safety

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