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At week 13, significant reductions versus placebo were observed in glycated hemoglobin (HbA1c: 0.87%), body weight (2.54%), systolic blood pressure (SBP: 3.84 mmHg), pulse pressure (3.81 mmHg), high-sensitivity C-reactive protein (hsCRP: 18.08%), and lipid parameters including total cholesterol (7.00%), nonHDL-C (8.02%), and triglycerides (8.15%)

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Additionally, the loss of fatty acids can affect the skin barrier, leading to dryness and a lacklustre appearance

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Retatrutide is a triple receptor agonist activating GLP-1R, GIPR, and GCG-R pathways to reduce appetite, improve insulin secretion, and support metabolic health

Purpose of Review PraderWilli syndrome (PWS) is a rare and complex genetic disorder with multiple effects on the metabolic, endocrine, and neurological systems, as well as behavioral and intellectual difficulties