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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

ANALYSIS METHODOLOGY For a deeper understanding of where off-label GLP-1 uses are emerging, Storyful Intelligence analyzed 29.9k mentions across conversations on X, Facebook, Reddit, and Instagram, from February 1, 2024, to March 24, 2025