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Therefore, in the next step, we aim to conduct the study on a more clinically relevant in vivo model, such as pigs, with a larger number of animals for each group

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Table 3 summarizes the PIONEER trial programmes [35,36,37,38,39,40,41,42,43,44]

Gene expression studies, as reviewed recently (9), have identified low mRNA levels of the G proteincoupled GLP-1 receptor in numerous kidney cell populations, including endothelial cells, vascular smooth muscle cells, and glomerular epithelial cells (also known as podocytes)

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All the companies are trying to have an edge over the other companies, Guirguis says