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Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion
Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system
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37 Through their anti-inflammatory and neuromodulatory actions, GLP-1 RAs may offer an additional mechanism for migraine control, particularly in cases with obesity, as it is a known risk factor for chronification
A second consequence of the use of GLP-1R agonists may be the higher-than-expected blood ethanol levels
