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5 Inflammation and oxidative stress It has been widely accepted that chronic low-grade inflammation is involved in the pathogenesis of PCOS, mainly owing to the excessive fat accumulation observed, particularly in the visceral adipose tissues (36, 37)

GLP-1: GLP-1(7-36) & GLP(9-36) GLP-1 is an endocrine peptide hormone synthesized in multiple locations including: 1) L-cells located in the intestinal mucosa, 2) -cells found in the pancreatic islet, and 3) central neurons residing in the nucleus of the solitary tract, a region regulating appetite and digestion (D'Alessio, 2016)

GLP-1 receptor agonists appear to influence several components of this system

It impacts around 18% of people with diabetes and exhibits a higher prevalence than in those without diabetes

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down
