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However, semaglutide therapy is also associated with concerning adverse effects like acute pancreatitis, anesthetic risks like pulmonary aspiration or residual gastric content, acute kidney injury, acute gallbladder injury, nonarteritic anterior ischemic optic neuropathy and diabetic retinopathy

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[16] Patients receiving hydrochlorothiazide and triamterene should be monitored closely for signs of electrolyte imbalance including hyperkalemia, hyponatremia, hypokalemia, hypomagnesemia, and hypochloremia

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While physiological ROS levels are necessary for sperm capacitation and fertilization, excessive ROS cause lipid peroxidation, DNA fragmentation, and protein oxidation, ultimately impairing sperm function [112,113,114,115,116,117]